Liu Mo Lung Driving (2024)

1. What links ventilator driving pressure with survival in the acute respiratory ...

  • 11 feb 2019 · Our results suggest a credible mechanistic explanation for the proposed association between driving pressure and relative risk of death.

  • Recent analyses of patient data in acute respiratory distress syndrome (ARDS) showed that a lower ventilator driving pressure was associated with reduced relative risk of mortality. These findings await full validation in prospective clinical ...

What links ventilator driving pressure with survival in the acute respiratory ...

2. Driving pressure of respiratory system and lung stress in mechanically ...

  • Meer resultaten van ccforum.biomedcentral.com

  • During control mechanical ventilation (CMV), the driving pressure of the respiratory system (ΔPrs) serves as a surrogate of transpulmonary driving pressure (ΔPlung). Expiratory muscle activity that decreases end-expiratory lung volume may impair the validity of ΔPrs to reflect ΔPlung. This prospective observational study in patients with acute respiratory distress syndrome (ARDS) ventilated with proportional assist ventilation (PAV+), aimed to investigate: (1) the prevalence of elevated ΔPlung, (2) the ΔPrs-ΔPlung relationship, and (3) whether dynamic transpulmonary pressure (Plungsw) and effort indices (transdiaphragmatic and respiratory muscle pressure swings) remain within safe limits. Thirty-one patients instrumented with esophageal and gastric catheters (n = 22) were switched from CMV to PAV+ and respiratory variables were recorded, over a maximum of 24 h. To decrease the contribution of random breaths with irregular characteristics, a 7-breath moving average technique was applied. In each patient, measurements were also analyzed per deciles of increasing lung elastance (Elung). Patients were divided into Group A, if end-inspiratory transpulmonary pressure (PLEI) increased as Elung increased, and Group B, which showed a decrease or no change in PLEI with Elung increase. In 44,836 occluded breaths, ΔPlung ≥ 12 cmH2O was infrequently observed [0.0% (0.0–16.9%) of measurements]. End-expiratory lung volume decrease, due to active expiration, was associated with underest...

Driving pressure of respiratory system and lung stress in mechanically ...

3. Effect of driving pressure on early postoperative lung gas distribution ...

  • 22 mei 2023 · We hypothesized that driving pressure-guided ventilation during supratentorial craniotomy might lead to a more homogeneous gas distribution in the lung ...

  • Neurosurgical patients represent a high-risk population for postoperative pulmonary complications (PPCs). A lower intraoperative driving pressure (DP) is related to a reduction in postoperative pulmonary complications. We hypothesized that driving ...

Effect of driving pressure on early postoperative lung gas distribution ...

4. Associations between changes in oxygenation, dead space and ...

  • The aim of the current study was to determine the prognostic capacity of changes in PaO2/FiO2, dead space fraction (VD/VT) and respiratory system driving ...

  • Associations between changes in oxygenation, dead space and driving pressure induced by the first prone position session and mortality in patients with acute respiratory distress syndrome

Associations between changes in oxygenation, dead space and ...

5. ‪Weihuang Liu‬ - ‪Google 学术搜索‬

‪Weihuang Liu‬ - ‪Google 学术搜索‬

6. [PDF] Driving pressure: applying the concept at the bedside

  • 16 mei 2023 · Driving pressure (ΔP) is defined as the distending pres- sure above the applied positive end-expiratory pressure.

7. Practice of diagnosis and management of acute respiratory ...

  • 28 sep 2018 · Pplat and driving pressure increased significantly in patients with a higher degree of ARDS severity (P=0.002 and P<0.001, respectively), but Vt ...

  • Practice of diagnosis and management of acute respiratory distress syndrome in mainland China: a cross-sectional study

Practice of diagnosis and management of acute respiratory ...

8. Role of Changes in Driving Pressure and Mechanical Power in ... - MDPI

  • 24 mrt 2023 · Except lung protective strategies, driving pressure (ΔP) and ... Liu, W.L.; Hsu, H.S. Maintenance of low driving pressure in patients ...

  • Driving pressure (ΔP) and mechanical power (MP) are associated with increased mortality in patients with acute respiratory distress syndrome (ARDS). We aimed to investigate which was better to predict mortality between changes in ΔP and MP. We reanalyzed data from a prospective observational cohort study of patients with ARDS in our hospital. Serial ΔP and MP values were calculated. The factors associated with survival were analyzed. Binary logistic regression showed that age (odds ratio (OR), 1.012; 95% confidence interval (CI), 1.003–1.022), Sequential Organ Failure assessment (SOFA) score (OR, 1.144; 95% CI, 1.086–1.206), trauma (OR, 0.172; 95% CI, 0.035–0.838), ΔP (OR, 1.077; 95% CI, 1.044–1.111), change in ΔP (OR, 1.087; 95% CI, 1.054–1.120), and change in MP (OR, 1.018; 95% CI, 1.006–1.029) were independently associated with 30-day mortality. Change in MP, change in ΔP, and SOFA scores were superior to ΔP in terms of the accuracy of predicting 30-day mortality. In conclusion, calculating change in ΔP is easy for respiratory therapists in clinical practice and may be used to predict mortality in patients with ARDS.

Role of Changes in Driving Pressure and Mechanical Power in ... - MDPI

9. Driver Oncogene Variations and Patients With Locally Advanced ...

  • 6 jun 2022 · Question Do driver variations in unresectable locally advanced non–small cell lung cancer (NSCLC) alter clinical outcomes of treatment with ...

  • This cohort study compares outcomes of 104 patients with unresectable locally advanced non–small cell lung cancer with and without driver variations treated with the PACIFIC regimen.

Driver Oncogene Variations and Patients With Locally Advanced ...

10. Uncommon/rare oncogenic drivers in non‐small cell lung cancer - SciOpen

  • 12 dec 2023 · ... Liu12 , Ji‐Wei Liu13 , Peng‐Hui Zhou6 , Wei‐Zhi Chen14 , Ling‐Hua ... MO lecular Pathology Committee of Chinese Society of Pathology.

  • The importance of uncommon/rare oncogenic drivers in non‐small cell lung cancer (NSCLC) was underscored during the 20th China Lung Cancer Summit. These drivers, while present in a significant proportion of NSCLC patients, remain a challenge for diagnosis and therapeutic targeting. In the never‐smokers/low smokers category with mutations such as EGFR and HER2, the efficacy of immune checkpoint inhibitors (ICIs) remains suboptimal, attributed to lower PD‐L1 expression and tumor mutation burden (TMB). However, heavy smokers, often with mutations like KRAS, may derive benefits from ICIs, as supported by trials like CheckMate‐057. With the complex landscape of these drivers and their clinical implications, the summit culminated in six pivotal consensus points, aiming to guide future research and clinical decisions. Despite the advancements, the detection, interpretation, and therapeutic strategies involving these drivers necessitate further exploration and standardization.

11. Qin Liu, PhD | Qin Liu Lab | Washington University in St. Louis

  • Her group aims to dissect the neuronal populations and circuits that drive allergic and infectious symptoms, including itchy, watery eyes, excessive sneezing, ...

  • Dr. Liu joined the Washington University School of Medicine in 2012 after she finished her postdoctoral training in the Department of Neuroscience at the Johns Hopkins School of Medicine. Using gen…

Qin Liu, PhD | Qin Liu Lab | Washington University in St. Louis

12. Mofang LiuDistinguished Adjunct Professor from CAS , PhD ...

  • 1. Jiang, Shuai*; Zhang, Hong-Wei; Lu, Ming-Hua; He, Xiao-Hong; Li, Yong; Gu, Hua; Liu, Mo-Fang#; Wang, En-Duo.MicroRNA-155 Functions as an OncomiR in Breast ...

  • 生命科学与技术学院

13. Anne Liu - Stanford Profiles

  • She has given presentations on antibiotic allergies, drug desensitization, and aspirin-exacerbated respiratory disease, among other topics. Dr. Liu's honors ...

  • Anne Liu is part of Stanford Profiles, official site for faculty, postdocs, students and staff information (Expertise, Bio, Research, Publications, and more). The site facilitates research and collaboration in academic endeavors.

14. Synthetic vectors for activating the driving axis of ferroptosis - Nature

  • 10 sep 2024 · Sijin Liu (Shandong First Medical University). Liver, lung and skin normal cells were extracted from mouse tissues. All cells were cultured in ...

  • Ferroptosis is a promising strategy for cancer therapy, with numerous inhibitors of its braking axes under investigation as potential drugs. However, few studies have explored the potential of activating the driving axes to induce ferroptosis. Herein, phosphatidylcholine peroxide decorating liposomes (LIPPCPO) are synthesized to induce ferroptosis by targeting divalent metal transporter 1 (DMT1). LIPPCPO is found to boost lysosomal Fe2+ efflux by inducing cysteinylation of lysosomal DMT1, resulting in glutathione peroxidase 4 (GPX4) suppression, glutathione depletion and ferroptosis in breast cancer cells and xenografts. Importantly, LIPPCPO induced ferroptotic cell death is independent of acquired resistance to radiation, chemotherapy, or targeted agents in 11 cancer cell lines. Furthermore, a strong synergistic ferroptosis effect is observed between LIPPCPO and an FDA-approved drug, artesunate, as well as X rays. The formula of LIPPCPO encapsulating artesunate significantly inhibits tumor growth and metastasis and improves the survival rate of breast cancer-bearing female mice. These findings provide a distinct strategy for inducing ferroptosis and highlight the potential of LIPPCPO as a vector to synergize the therapeutic effects of conventional ferroptosis inducers. Inducers of ferroptosis hold potential for cancer therapy. Here, the authors identify a peroxide-decorated liposome capable of inducing ferroptosis and enhancing the efficacy of chemotherapeutic agents and rad...

Synthetic vectors for activating the driving axis of ferroptosis - Nature

15. Mitochondrial DNA mutations drive aerobic glycolysis to enhance ...

  • 29 jan 2024 · Liu (Broad Institute, USA). TALEs were synthesized ... Respiratory complex and tissue lineage drive recurrent mutations in tumor mtDNA.

  • The mitochondrial genome (mtDNA) encodes essential machinery for oxidative phosphorylation and metabolic homeostasis. Tumor mtDNA is among the most somatically mutated regions of the cancer genome, but whether these mutations impact tumor biology is debated. We engineered truncating mutations of the mtDNA-encoded complex I gene, Mt-Nd5, into several murine models of melanoma. These mutations promoted a Warburg-like metabolic shift that reshaped tumor microenvironments in both mice and humans, consistently eliciting an anti-tumor immune response characterized by loss of resident neutrophils. Tumors bearing mtDNA mutations were sensitized to checkpoint blockade in a neutrophil-dependent manner, with induction of redox imbalance being sufficient to induce this effect in mtDNA wild-type tumors. Patient lesions bearing >50% mtDNA mutation heteroplasmy demonstrated a response rate to checkpoint blockade that was improved by ~2.5-fold over mtDNA wild-type cancer. These data nominate mtDNA mutations as functional regulators of cancer metabolism and tumor biology, with potential for therapeutic exploitation and treatment stratification. Gammage and colleagues find that mitochondrial DNA mutations induce alterations in redox metabolism, a remodeled tumor microenvironment characterized by a loss of neutrophils and consequently enhanced responses to immunotherapy in melanoma.

Mitochondrial DNA mutations drive aerobic glycolysis to enhance ...

16. Vincent Liu | University of Iowa Health Care

  • 865 Lincoln Road. Bettendorf, IA 52722. Get Directions · Medical Center. 200 Hawkins Drive. Iowa City, IA ... mo r tar-pestel mosqui t o music-note n95-mask ...

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Vincent Liu | University of Iowa Health Care

17. Early Detection of Molecular Residual Disease in Localized Lung Cancer ...

  • mo, months; tx, treatment; adeno, adenocarcinoma; squam, squamous cell ... drive lung cancers (12, 13, 27, 28). In a separate study, the TracerX ...

  • ctDNA profiling of pre- and post-treatment samples from patients with localized lung cancer identifies the presence of minimal residual disease earlier than standard imaging.

Early Detection of Molecular Residual Disease in Localized Lung Cancer ...

18. Analysis of water use efficiency and driving factors in the Beijing ...

  • LONG Xuezhi, LIU Suxia, MO Xingguo, CHEN Xuejuan. ... Analysis of water use efficiency and driving ... Reappraisal of extravascular lung thermal volume as a measure ...

  • Agricultural irrigation accounts for>65% of water use in the Beijing-Tianjin-Hebei Province Plain. Improving the agricultural water use efficiency will help relieve the pressure on the water resources found in the Beijing-Tianjin-Hebei Plain and promote sustainable development. Based on water use efficiency (WUE), net primary productivity (NPP), and actual evapotranspiration (ETa) from 1980 to 2013 simulated by the VIP model, combined with the annual mean air temperature (Tmean), annual precipitation (Pre), and annual sunshine duration (Sun), the Copula method was used to create five groups of joint probability distributions:WUE and NPP, ETa, Tmean, Pre, and Sun. Conditional probability was calculated based on the hypothesis that WUE was greater than any particular value under low, medium, and high value ranges of each driving factor. The findings showed that the greater the values of NPP, ETa, and Sun, the more likely was WUE to be greater than any particular value. However, the lower the values of Tmean and Pre, the more likely was WUE to be greater than any particular value. The sensitivity of WUE to variation in the value of each driving factor was reflected by the difference of the conditional probability of WUE under high and low value ranges, suggesting that WUE was most sensitive to the variation in the value of NPP followed by those of Sun, ETa, Pre, and Tmean. Comparison of the conditional probabilities of WUE under the same value conditions of NPP, ETa, Tmean, P...

Analysis of water use efficiency and driving factors in the Beijing ...
Liu Mo Lung Driving (2024)
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